How whole genome sequencing data is actually shared in clinical practice - a bottleneck for precision medicine

Precision medicine won’t scale without precision data sharing. A recent review in Computers in Biology and Medicine explores one of the biggest bottlenecks in genomic medicine: how whole genome sequencing data is actually shared in clinical practice.

The key insight? Research-grade data sharing is not the same as clinical-grade data sharing.

While research infrastructures have advanced rapidly, there is still no widely adopted, scalable system for sharing whole-genome data in routine clinical care. The barriers are not sequencing costs anymore. They are governance, interoperability, accreditation, and trust.

Most national genome initiatives talk about “precision medicine.” Far fewer articulate how clinical-grade genomic data will be securely stored, integrated into EHRs, governed across jurisdictions, and reused in real-world care.
This is exactly the infrastructure challenge initiatives like PrecisionGo are designed to address.

Generating multi-omics data is only step one. Building interoperable, accredited, clinician-ready data ecosystems is the real translational work.

If you’re working in genomics, digital health, or research infrastructure, this is well worth your time: https://www.sciencedirect.com/science/article/pii/S0010482525016890?via%3Dihub