Nature Medicine paper brings precision medicine closer to the clinical interface for neurodegenerative disease
PrecisionGo is proud to celebrate the groundbreaking work of Dr Caitlin Finney and Dr Artur Shvetcov, whose new Nature Medicine paper brings precision medicine a step closer to the clinical interface for neurodegenerative disease.
Working with their team at The Westmead Institute for Medical Research and global collaborators, they used large-scale proteomics from the Global Neurodegeneration Proteomics Consortium, bioinformatics and machine learning to reveal how the APOE ε4 genetic variant influences risk for Alzheimer’s, Parkinson’s, ALS and frontotemporal dementia. Analysing over 11,000 samples from 20+ cohorts, they identified a consistent immune-related protein signature in APOE ε4 carriers - reframing it as a broad immune modulator rather than a marker for one disease.
🧬 Why it matters:
This discovery moves us closer to blood-based biomarkers for earlier detection and tailored prevention - turning multi-omics discoveries into real-world clinical tools.
